Disability outcomes of early cerebellar and brainstem symptoms in multiple sclerosis

M Le; C Malpas; S Sharmin; D Horáková; E Havrdova; M Trojano; G Izquierdo; S Eichau; S Ozakbas; A Lugaresi; A Prat; M Girard; P Duquette; C Larochelle; R Alroughani; R Bergamaschi; P Sola; D Ferraro; P Grammond; F Grand’ Maison; M Terzi; C Boz; R Hupperts; H Butzkueven; E Pucci; F Granella; V Van Pesch; A Soysal; BI Yamout; J Lechner-Scott; DLA Spitaleri; R Ampapa; R Turkoglu; G Iuliano; C Ramo-Tello; JL Sanchez-Menoyo; Y Sidhom; R Gouider; V Shaygannejad; J Prevost; A Altintas; YD Fragoso; PA McCombe; T Petersen; M Slee; MH Barnett; S Vucic; A Van Der Walt; T Kalincik

Journal article

Disability outcomes of early cerebellar and brainstem symptoms in multiple sclerosis

M Le, C Malpas, S Sharmin, D Horáková, E Havrdova, M Trojano, G Izquierdo, S Eichau, S Ozakbas, A Lugaresi, A Prat, M Girard, P Duquette, C Larochelle, R Alroughani, R Bergamaschi, P Sola, D Ferraro, P Grammond, F Grand’ Maison Show all

Multiple Sclerosis Journal | SAGE PUBLICATIONS LTD | Published : 2021

DOI: 10.1177/1352458520926955

Abstract

Background: Cerebellar and brainstem symptoms are common in early stages of multiple sclerosis (MS) yet their prognostic values remain unclear. Objective: The aim of this study was to investigate long-term disability outcomes in patients with early cerebellar and brainstem symptoms. Methods: This study used data from MSBase registry. Patients with early cerebellar/brainstem presentations were identified as those with cerebellar/brainstem relapse(s) or functional system score ⩾ 2 in the initial 2 years. Early pyramidal presentation was chosen as a comparator. Andersen-Gill models were used to compare cumulative hazards of (1) disability progression events and (2) relapses between patients wit..

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University of Melbourne Researchers

Charles Malpas Author

Sifat Sharmin Author

Tomas Kalincik Author

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Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was financially supported by the National Health and Medical Research Council (1140766, 1129189, 1157717).